Research Studies

Study Title

Healey Platform Trial

Enrollment Status

Current

Principal Investigators

Michael Benatar, MD, PhD

Study Type

Drug Trial

Goals

Evaluate the safety and efficacy of multiple experimental agents compared to shared placebo, under the auspice of a single platform trial The first agents to be evaluated include: Zilucoplan, Verdiperstat, Bioenergetic nanocatalysis (CNM-Au8-nanocrystaline gold), and pridopidine

Enrolling

ALS patients

Eligibility

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Clinical diagnosis of ALS
Onset of weakness within the past 36 months
Breathing function (vital capacity) at least 50% of normal
Regimen-specific eligibility criteria may also apply

Study Involvement

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Multiple study visits over a period of 28 weeks
Study procedures include:

  • Medical history and medication review
  • Drug dosing with compliance tracking
  • Breathing tests
  • Questionnaires/surveys
  • Physical exam
  • Neurological exam
  • Electrocardiogram (EKG)
  • Blood and urine collection
  • Optional: DNA and CSF collection

Option to continue to open label or re-randomized to receive a new experimental agent

Primary Funding Source

Healey ALS Center

Related Publications

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Related Presentations & Lectures

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